Oxford boss Graham Rix has released six senior players following the U's failure to reach the play-offs.
Andy Woodman, Matt Bound, Lee Steele, Richard Walker, Manny Omoyinmi and Courtney Pitt will not be retained.
Experienced defender Paul McCarthy is also leaving after turning down a new deal to stay with the club.
But Dean Whitehead, Chris Hackett, Scott McNiven, Andy Crosby, James Hunt, Matt Robinson, Jefferson Louis and Dave Waterman have been offered contracts.
Goalkeeper Simon Cox and midfielder Danny Brown are also staying on after the option of a 12-month contract extension was taken up.